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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - cIAP1 E3 ligase inhibitor D19

cIAP1 E3 ligase inhibitor D19

CAS No. 380640-76-6

cIAP1 E3 ligase inhibitor D19( cIAP1 inhibitor D19 )

Catalog No. M14312 CAS No. 380640-76-6

cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    cIAP1 E3 ligase inhibitor D19
  • Note
    Research use only, not for human use.
  • Brief Description
    cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM.
  • Description
    cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1; binds to the RING domain of cIAP1 and inhibits the E3 ligase activity of cIAP1 by interfering with the dynamics of its interaction with E2, inhibited cIAP1 autoubiquitination with all of the E2s (t UbcH5a/b/c, UbcH6, and Ubc13/Uev1a) that can mediate its activity; suppresses c-MYC oncogenic function and cancer cell proliferation by stabilizing MAD1 protein and promoting the degradation of c-MYC.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    cIAP1 inhibitor D19
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    380640-76-6
  • Formula Weight
    325.404
  • Molecular Formula
    C16H11N3OS2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=C(/C=N/NC2=NC3=CC=CC=C3S2)SC4=CC=CC=C41
  • Chemical Name
    (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)benzo[b]thiophen-3-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li H, et al. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201807711.
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